Surgical treatment for anal intraepithelial neoplasia

The rate of progression from pre-cancer to cancer is not known, but may be of the order of 1 in per year for HIV negative people and 1 in per year for those with HIV. Grade 3 is regarded as more serious than grade 2. Many AIN1 lesions are entirely benign and never progress. Most people are likely to be unaware they have the condition, unless they have special tests performed on the anus It has been estimated that around 1 in such men will progress to cancer each year. A small, unknown, proportion of women develops anal HSIL. It is approximately 10 times more common in women who have a history of HPV-related abnormalities in the cervix, vagina or vulva.
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Anal pre-cancer (anal intraepithelial neoplasia)

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Anal intraepithelial neoplasia | Anal cancer | Cancer Research UK

Anal squamous cell cancer is an uncommon malignancy caused by infection with oncogenic strains of Human papilloma virus. Anal cancer is much more common in immunocompromised persons, including those infected with Human immunodeficiency virus. High-grade anal intraepithelial neoplasia HGAIN , the precursor of anal cancer, is identified by clinicians providing care for patients with anorectal disease, and is increasingly being identified during screening of immunosuppressed patients for anal dysplasia. This led to the suggestion by some that treatment for HGAIN should be delayed until patients developed anal cancer. Alternative approaches in identification and treatment have been developed to treat patients with multifocal or extensive HGAIN lesions. High-resolution anoscopy combines magnification with anoscopy and is being used to identify HGAIN and determine treatment margins. HGAIN can then be ablated with a number of modalities, including infrared coagulation, CO 2 laser, and electrocautery.
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Anal Intraepithelial Neoplasia

If you have symptoms of cancer contact your doctor. Read our information about coronavirus and cancer. Anal intraepithelial neoplasia AIN means there are abnormal cells in the lining of your anus. A pathologist looks at your cells under a microscope to check whether your anal cells look different to normal anal cells.
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Anal intraepithelial neoplasia, a premalignant condition, is a difficult problem of the anal canal and margin. The disorder most commonly causes no discernible symptoms; yet patient concern and treatment uncertainties render anal intraepithelial neoplasia challenging to treat. Treatment difficulties are related to adequately tailoring care to the patient, without over- or undertreating the problem. At this time, the regimen most commonly practiced by physicians with experience in treating anal neoplasia is close follow-up through careful examination unless other factors force intervention.
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