Normal liver expresses MAT1A, which is silenced in hepatocellular carcinoma. We have shown that hepatoma cells overexpressing MAT1A grew slower, but whether this is also true in vivo remains unknown. To investigate the effect of overexpressing MAT1A on in vivo tumorigenesis, we generated stable transfectants of Huh7 cells overexpressing either MAT1A or empty vector. Tumor properties such as proliferation, angiogenesis, and apoptosis were compared, and microarray analysis was performed. Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine incorporation than control cells.
A group of staunchly conservative women has laid bare a bold plan to protest high taxes. The Lady Godiva Coalition, as the anti-tax crusaders call themselves, announced yesterday that they will strut their stuff on April 17, Tax Day. Some of the most prominent female conservatives in the country may join in the flesh-flaunting procession. The shocking strategy worked like a charm. Her mortified mate Leofric, Earl of Mercia, hurriedly scuttled the tax hike. Left-wing environmental, anti-war and animal-rights groups — most notably PETA — have resorted to buns-baring tactics many times over the past few decades.